Ipamorelin vs Sermorelin
Strength for strength, Ipamorelin costs less per mg at the two strengths both are offered in: at 5mg $0.764 per mg against $1.600 (IP5, SMO5 in 50-box lots), at 10mg $0.553 per mg against $1.486 (IP10, SMO10 in 50-box lots). By the single box, Ipamorelin is the only option, from $0.553 per mg at 10mg (IP10); every Sermorelin line is special order. Ipamorelin is offered in 3 strengths (2mg to 10mg), Sermorelin in 2 (5mg to 10mg). Neither is on the shelf today. The least either takes: one box of IP5 at $38.20, three for a first order’s $100 minimum, against 50 boxes of SMO5, $3,999.50 of goods.
Prices revised · USD per box of ten · freight included to US addresses from $1,000 of goods · COA per batch · research use only · New to us? What can be checked before you pay
What differs between Ipamorelin and Sermorelin
Two different classes that are often weighed against each other. Ipamorelin is a synthetic pentapeptide amide built from unnatural residues, Aib and a D-2-naphthylalanine among them, at about 711.9 mass units, with no methionine, tryptophan or cysteine to oxidise. Sermorelin is the first 29 residues of human GHRH as an amide, a natural sequence six times the size, with a methionine at 27, 16 heavier as the sulfoxide, and the deamidation site of asparagine 8. Of the two, only the longer chain has a methionine to oxidise or an asparagine to deamidate; both end in an amide.
| Detail | Ipamorelin | Sermorelin |
|---|---|---|
| Best per mg, by the box | $0.553 per mg (IP10) | Special order only |
| Best per mg, special order included | $0.553 per mg (IP10) | $1.486 per mg (SMO10, 50 boxes) |
| Price per box sold singly | $38.20 to $55.30 | Special order only |
| In 50-box lots, per box | $22.20 | $79.99 to $148.55 |
| Strengths offered | 3: 2mg, 5mg, 10mg | 2: 5mg, 10mg |
| Highest price per mg | $1.110 per mg (IP2, 50 boxes) | $1.600 per mg (SMO5, 50 boxes) |
| On the shelf today | 0 of 3 strengths | 0 of 2 strengths |
| Range | Growth & IGF | Growth & IGF |
| Form | Lyophilised powder | Lyophilised powder |
| Molecular weight | 711.9 g/mol | 3,357.9 g/mol |
| Formula | C38 |
C149 |
| CAS number | 170851-70-4 | 86168-78-7 |
| Release limit | Purity ≥ 98.0 % by RP-HPLC | Purity ≥ 98.0 % by RP-HPLC |
Each line’s own page: Ipamorelin and Sermorelin. Reading either certificate: how to read a peptide COA. Checking a batch: verify a batch number. Every line priced: the price list. Checking another supplier’s quote: the price per mg calculator.
Strength for strength
Every strength both are offered in, per mg, the lower figure in bold; stock as this page was opened.
| Strength | Ipamorelin | Sermorelin |
|---|---|---|
| 5mg | $0.764 per mg (lower) (IP5, made to order) | $1.600 per mg (SMO5, special order, 50 boxes) |
| 10mg | $0.553 per mg (lower) (IP10, made to order) | $1.486 per mg (SMO10, special order, 50 boxes) |
Every strength of both
Compared elsewhere
Ipamorelin vs GHRP-2
At 10mg: $0.553 per mg against $0.727 (GHRP-2, 50-box lots); 3 strengths against 2.
Ipamorelin vs Tesamorelin
At 10mg: $0.553 per mg against $2.258; 3 strengths against 4.
Hexarelin vs Ipamorelin
At 5mg: $1.454 per mg (Hexarelin, 50-box lots) against $0.764; 2 strengths against 3.
CJC-1295 vs Ipamorelin
At 10mg: $1.042 per mg against $0.553; 1 strength against 3.
Ipamorelin vs GHRP-6
At 10mg: $0.553 per mg against $0.783 (GHRP-6, 50-box lots); 3 strengths against 2.
CJC-1295 no DAC vs Ipamorelin
At 10mg: $1.747 per mg against $0.553; 3 strengths each.
Questions
What is the difference between Ipamorelin and Sermorelin?
Two different classes that are often weighed against each other. Ipamorelin is a synthetic pentapeptide amide built from unnatural residues, Aib and a D-2-naphthylalanine among them, at about 711.9 mass units, with no methionine, tryptophan or cysteine to oxidise.
Which of the two is a natural sequence?
Sermorelin: residues 32 to 60 of the GHRH precursor in UniProt (P01286), the first 29 of the hormone, with an amide on arginine 29 that the native hormone, which runs on to residue 44, does not have there. Ipamorelin is wholly synthetic, with Aib, a D-2-naphthylalanine and a D-phenylalanine among its five residues.
Does ipamorelin have any residue in common with sermorelin’s 29?
Two kinds only. Sermorelin carries lysine twice, at 12 and 21, and ipamorelin closes on one as the amide, L in both; sermorelin’s phenylalanine at 6 is the L form and ipamorelin’s at 4 the D. Nothing else carries over: sermorelin holds no histidine, Aib or naphthylalanine, and ipamorelin none of sermorelin’s tyrosines, arginines or aspartates, nor its methionine or asparagine. So three of ipamorelin’s five residues have no counterpart anywhere in the longer chain.
Which is cheaper per mg, Ipamorelin or Sermorelin?
Strength for strength, Ipamorelin costs less per mg at the two strengths both are offered in: at 5mg $0.764 per mg against $1.600 (IP5, SMO5 in 50-box lots), at 10mg $0.553 per mg against $1.486 (IP10, SMO10 in 50-box lots).
What are the molecular weights of Ipamorelin and Sermorelin?
Ipamorelin’s calculated average mass is 711.9 g/mol and Sermorelin’s 3,357.9 g/mol, 2,646.0 apart; in electrospray the ions come at m/z 712.9 (1+) for Ipamorelin against 1120.3 and 840.5 (3+ and 4+) for Sermorelin. On each certificate the measured mass is matched to the line’s calculated average mass, within about one unit, as how to read a peptide COA sets out.
Are Ipamorelin and Sermorelin made to the same specification?
Yes: both are supplied to purity not less than 98.0 percent by RP-HPLC and net content within 5 percent of label, and each certificate reports those with a measured mass, matched to the calculated figure on each sheet. The retest date is on the batch record. What differs is each molecule’s own chemistry, described on its compound page.
Structural facts from each compound’s sheet and profile; prices and stock from the list at the moment this page was opened. How to compare strengths on price.