Sermorelin vs Tesamorelin
Strength for strength, Sermorelin costs less per mg at the two strengths both are offered in: at 5mg $1.600 per mg against $2.400 (SMO5 in 50-box lots, TSM5), at 10mg $1.486 per mg against $2.258 (SMO10 in 50-box lots, TSM10). By the single box, Tesamorelin is the only option, from $2.180 per mg at 20mg (TSM20); every Sermorelin line is special order. Sermorelin is offered in 2 strengths (5mg to 10mg), Tesamorelin in 4 (2mg to 20mg); Tesamorelin has 3 on the shelf today, Sermorelin none (special order, 50-box minimum). The least either takes: one box of TSM5 at $119.99, against 50 boxes of SMO5, $3,999.50 of goods.
Prices revised · USD per box of ten · freight included to US addresses from $1,000 of goods · COA per batch · research use only · New to us? What can be checked before you pay
What differs between Sermorelin and Tesamorelin
Both come from human GHRH and part at the ends: sermorelin is the hormone’s first 29 residues, GHRH (1-29), with an amide on arginine 29 that the hormone itself does not carry; tesamorelin is all 44, GHRH (1-44), ending in the hormone’s own leucine amide, with a trans-3-hexenoyl cap on tyrosine 1, so its N-terminus has no free amine. In the precursor’s numbering (UniProt P01286) the two are residues 32 to 60 and 32 to 75. Methionine 27 is in both, so either can form a sulfoxide about 16 mass units up, and tesamorelin has more deamidation sites, two asparagines and five glutamines against one and two. Tesamorelin is the heavier chain, 5,135.9 in average mass to sermorelin’s 3,357.9.
| Detail | Sermorelin | Tesamorelin |
|---|---|---|
| Best per mg, by the box | Special order only | $2.180 per mg (TSM20) |
| Best per mg, special order included | $1.486 per mg (SMO10, 50 boxes) | $2.180 per mg (TSM20) |
| Price per box sold singly | Special order only | $119.99 to $436.00 |
| In 50-box lots, per box | $79.99 to $148.55 | $51.94 |
| Strengths offered | 2: 5mg, 10mg | 4: 2mg, 5mg, 10mg, 20mg |
| Highest price per mg | $1.600 per mg (SMO5, 50 boxes) | $2.597 per mg (TSM2, 50 boxes) |
| On the shelf today | 0 of 2 strengths | 3 of 4 strengths |
| Range | Growth & IGF | Growth & IGF |
| Also called | No other name | TH9507 |
| Form | Lyophilised powder | Lyophilised powder |
| Molecular weight | 3,357.9 g/mol | 5,135.9 g/mol |
| Formula | C149 |
C221 |
| CAS number | 86168-78-7 | 218949-48-5 |
| Release limit | Purity ≥ 98.0 % by RP-HPLC | Purity ≥ 98.0 % by RP-HPLC |
Each line’s own page: Sermorelin and Tesamorelin. Reading either certificate: how to read a peptide COA. Checking a batch: verify a batch number. Every line priced: the price list. Checking another supplier’s quote: the price per mg calculator.
Strength for strength
Every strength both are offered in, per mg, the lower figure in bold; stock as this page was opened. Counting special-order lines, sold in 50-box lots, the lowest for Sermorelin is $1.486 per mg (10mg, SMO10); for Tesamorelin it is still TSM20, on the shelf by the single box, at $2.180 per mg.
| Strength | Sermorelin | Tesamorelin |
|---|---|---|
| 5mg | $1.600 per mg (lower) (SMO5, special order, 50 boxes) | $2.400 per mg (TSM5, low stock) |
| 10mg | $1.486 per mg (lower) (SMO10, special order, 50 boxes) | $2.258 per mg (TSM10, low stock) |
Every strength of both
Compared elsewhere
Ipamorelin vs Sermorelin
At 10mg: $0.553 per mg against $1.486 (Sermorelin, 50-box lots); 3 strengths against 2.
CJC-1295 no DAC vs Sermorelin
At 10mg: $1.747 per mg against $1.486 (Sermorelin, 50-box lots); 3 strengths against 2.
Ipamorelin vs Tesamorelin
At 10mg: $0.553 per mg against $2.258; 3 strengths against 4.
CJC-1295 no DAC vs Tesamorelin
At 10mg: $1.747 per mg against $2.258; 3 strengths against 4.
CJC-1295 vs Tesamorelin
At 10mg: $1.042 per mg against $2.258; 1 strength against 4.
Questions
What is the difference between Sermorelin and Tesamorelin?
Both come from human GHRH and part at the ends: sermorelin is the hormone’s first 29 residues, GHRH (1-29), with an amide on arginine 29 that the hormone itself does not carry; tesamorelin is all 44, GHRH (1-44), ending in the hormone’s own leucine amide, with a trans-3-hexenoyl cap on tyrosine 1, so its N-terminus has no free amine.
Which CAS numbers belong to sermorelin and tesamorelin?
Two each, the peptide and its acetate. Sermorelin is 86168-78-7 (FDA UNII 89243S03TE) and sermorelin acetate 114466-38-5 (UNII 00IBG87IQW); tesamorelin is 218949-48-5 (UNII MQG94M5EEO) and tesamorelin acetate 901758-09-6 (UNII LGW5H38VE3). The specification sheets for both lines carry the peptide’s number; a number filed for an acetate names the salt, not another compound.
Which is cheaper per mg, Sermorelin or Tesamorelin?
Strength for strength, Sermorelin costs less per mg at the two strengths both are offered in: at 5mg $1.600 per mg against $2.400 (SMO5 in 50-box lots, TSM5), at 10mg $1.486 per mg against $2.258 (SMO10 in 50-box lots, TSM10).
What are the molecular weights of Sermorelin and Tesamorelin?
Sermorelin’s calculated average mass is 3,357.9 g/mol and Tesamorelin’s 5,135.9 g/mol, 1,778.0 apart; in electrospray the ions come at m/z 1120.3 and 840.5 (3+ and 4+) for Sermorelin against 1713.0 and 1285.0 (3+ and 4+) for Tesamorelin. On each certificate the measured mass is matched to the line’s calculated average mass, within about one unit, as how to read a peptide COA sets out.
Are Sermorelin and Tesamorelin made to the same specification?
Yes: both are supplied to purity not less than 98.0 percent by RP-HPLC and net content within 5 percent of label, and each certificate reports those with a measured mass, matched to the calculated figure on each sheet. The retest date is on the batch record. What differs is each molecule’s own chemistry, described on its compound page.
Structural facts from each compound’s sheet and profile; prices and stock from the list at the moment this page was opened. How to compare strengths on price.