Thymosin Alpha-1 vs TB-500 (thymosin beta-4 acetate)
Strength for strength, TB-500 costs less per mg at the two strengths both sell by the single box: at 5mg $1.428 per mg against $2.313 (TB5, TA5), at 10mg $1.034 per mg against $2.170 (TB10, TA10). Thymosin Alpha-1 is offered in 3 strengths (2mg to 10mg), TB-500 in 3 (2mg to 10mg); 1 and 2 of those are on the shelf today.
Prices revised · USD per box of ten · freight included to US addresses from $1,000 of goods · COA per batch · research use only · New to us? What can be checked before you pay
What differs between Thymosin Alpha-1 and TB-500
Both are acetylated synthetic peptides named for the thymus, and there the resemblance ends: thymosin alpha-1 is 28 residues, strongly acidic, with no methionine or tryptophan to oxidise, while TB-500, the 43-residue thymosin beta-4 sequence, has a methionine at 6 whose sulfoxide weighs 4,979.5 against 4,963.5. Average masses 3,108.3 and 4,963.5 g/mol; strengths and prices below.
| Detail | Thymosin Alpha-1 | TB-500 |
|---|---|---|
| Best price per mg | $2.170 per mg (TA10) | $1.034 per mg (TB10) |
| Price per box sold singly | $115.64 to $217.04 | $71.40 to $103.40 |
| In 50-box lots, per box | $50.90 | $28.00 |
| Strengths offered | 3: 2mg, 5mg, 10mg | 3: 2mg, 5mg, 10mg |
| Highest price per mg | $2.545 per mg (TA2, 50 boxes) | $1.428 per mg (TB5) |
| On the shelf today | 1 of 3 strengths | 2 of 3 strengths |
| Range | Longevity & Nootropic | Repair & Recovery |
| Also called | thymalfasin and FF-51 | timbetasin |
| Form | Lyophilised powder | Lyophilised powder |
| Molecular weight | 3,108.3 g/mol | 4,963.5 g/mol |
| Formula | C129 |
C212 |
| CAS number | 62304-98-7 | 77591-33-4 |
| Release limit | Purity ≥ 98.0 % by RP-HPLC | Purity ≥ 98.0 % by RP-HPLC |
Each line’s own page: Thymosin Alpha-1 and TB-500 (thymosin beta-4 acetate). Reading either certificate: how to read a peptide COA. Checking a batch: verify a batch number. Every line priced: the price list. Checking another supplier’s quote: the price per mg calculator.
Strength for strength
Every strength both are offered in, per mg, the lower figure in bold; stock as this page was opened.
| Strength | Thymosin Alpha-1 | TB-500 |
|---|---|---|
| 2mg | $2.545 per mg (TA2, special order, 50 boxes) | $1.400 per mg (lower) (TB2, special order, 50 boxes) |
| 5mg | $2.313 per mg (TA5, made to order) | $1.428 per mg (lower) (TB5, in stock) |
| 10mg | $2.170 per mg (TA10, low stock) | $1.034 per mg (lower) (TB10, low stock) |
Every strength of both
Compared elsewhere
Thymalin vs Thymosin Alpha-1
At 10mg: $0.925 per mg (Thymalin, 50-box lots) against $2.170; 1 strength against 3.
BPC-157 vs TB-500
At 10mg: $0.553 per mg against $1.034; 3 strengths each.
GHK-Cu vs TB-500
$0.052 per mg against $1.034 per mg at best; 2 strengths against 3.
Questions
What is the difference between Thymosin Alpha-1 and TB-500?
Both are acetylated synthetic peptides named for the thymus, and there the resemblance ends: thymosin alpha-1 is 28 residues, strongly acidic, with no methionine or tryptophan to oxidise, while TB-500, the 43-residue thymosin beta-4 sequence, has a methionine at 6 whose sulfoxide weighs 4,979.5 against 4,963.5.
Where do thymosin alpha-1 and TB-500 sit in their human proteins?
In two different precursors, each with its initiator methionine removed and the serine after it acetylated: thymosin alpha-1 takes positions 2 to 29 of prothymosin alpha, a 111-residue protein (UniProt P06454), and TB-500 covers residues 2 to 44 of thymosin beta-4 (UniProt P62328). Their international names differ too: thymalfasin (WHO proposed list 77) for thymosin alpha-1, timbetasin (list 118) for the full thymosin beta-4 chain.
Which is cheaper per mg, Thymosin Alpha-1 or TB-500?
Strength for strength, TB-500 costs less per mg at the two strengths both sell by the single box: at 5mg $1.428 per mg against $2.313 (TB5, TA5), at 10mg $1.034 per mg against $2.170 (TB10, TA10).
What are the molecular weights of Thymosin Alpha-1 and TB-500?
Thymosin Alpha-1’s calculated average mass is 3,108.3 g/mol and TB-500’s 4,963.5 g/mol, 1,855.2 apart; in electrospray the ions come at m/z 1037.1 and 778.1 (3+ and 4+) for Thymosin Alpha-1 against 1655.5 and 1241.9 (3+ and 4+) for TB-500. On each certificate the measured mass is matched to the line’s calculated average mass, within about one unit, as how to read a peptide COA sets out.
Are Thymosin Alpha-1 and TB-500 made to the same specification?
Yes: both are supplied to purity not less than 98.0 percent by RP-HPLC and net content within 5 percent of label, and each certificate reports those with a measured mass, matched to the calculated figure on each sheet. The retest date is on the batch record. What differs is each molecule’s own chemistry, described on its compound page.
Structural facts from each compound’s sheet and profile; prices and stock from the list at the moment this page was opened. How to compare strengths on price.