TB-500 (thymosin beta-4 acetate) wholesale
Thymosin beta-4, also called timbetasin. Bulk peptide powder in 10-vial kits, for sale in the USA and abroad: price and cost per mg
About TB-500 (thymosin beta-4 acetate)
Synthetic N-acetylated 43-residue peptide, Ac-SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA GES. 3 vial strengths, 2mg to 10mg, from $71.40 to $103.40 per box of ten, in US dollars (special-order lines from $28.00 a box at 50 boxes). 2 strengths are on the shelf, leaving in 1 to 2 business days; the other is special order, with a 50-box minimum.
Documents Specification sheet Verify a batch How to read the certificate What the purity figure means The mass result, explained
TB-500 (thymosin beta-4 acetate) price per box, per vial and per mg
| Code | Strength | Per box | Per vial | Per mg | Stock | Order |
|---|---|---|---|---|---|---|
| TB2 | 2mg x 10 vials | $28.00 | $2.80 | $1.400 per mg | Special order, 50-box minimum | |
| TB5 | 5mg x 10 vials | $71.40 | $7.14 | $1.428 per mg | In stock | |
| TB10 | 10mg x 10 vials | $103.40 | $10.34 | Lowest $1.034 per mg | Low stock |
On the shelf, leaving in 1 to 2 business days: TB5, TB10. The others are special order, with a 50-box minimum.
Ships from the USA: to US addresses at our risk until delivered (DAP), freight included from $1,000 of goods; to Canada and most other countries through the desk · on-shelf lines leave in 1 to 2 business days, then 1 to 3 business days in US transit · COA per batch · proforma in USD, paid by card, Wise, e-Transfer (Canada), Bitcoin or USDT · prices revised
Stock key
- In stock
- on the shelf, leaves in 1 to 2 business days once payment clears
- Low stock
- on the shelf and running low; leaves in 1 to 2 business days
- Ships in 1 week
- on its way in
- Ships in 2 weeks
- on order
- Made to order, 4 weeks
- made for the order, about four weeks
- Special order, 50-box minimum
- brought in on a 50-box minimum rather than held in stock; the desk confirms the date before you pay
Prices are in US dollars per sealed box. Per unit is the box price over the milligrams, millilitres or units in the box.
TB-500 (thymosin beta-4 acetate) in brief
TB-500 (thymosin beta-4 acetate) comes in 3 strengths from 2mg to 10mg per vial, each a sealed box of ten, from $71.40 to $103.40 a box for the strengths sold singly. Per mg the spread is wide: TB10 (10mg x 10 vials) works out at $1.034 per mg against $1.428 per mg for TB5 (5mg x 10 vials), 28 percent less for the same mg, because the vial, the fill and the testing cost about the same whatever the vial holds.
2 of the 3 strengths are on the shelf today (TB5 and TB10) and leave in 1 to 2 business days after payment clears; TB10 is running low. TB2 is special order: brought in on a 50-box minimum rather than held in stock; ask the desk for the date before ordering.
What TB-500 (thymosin beta-4 acetate) is
TB-500 is the synthetic 43-residue sequence of thymosin beta-4 with an acetylated N-terminus, average mass 4963.5, supplied as the acetate. It is a very hydrophilic, highly charged chain: nine lysines and eleven glutamates or aspartates, which is why it takes many charges in electrospray.
There is one methionine, at position 6, and its sulfoxide is the related substance to expect for this line; it grows with air and light. There are also one asparagine and three glutamines that deamidate slowly. Store dry at minus 20. Oxidised at that methionine, the chain weighs 16 more, 4,979.5 against 4,963.5.
Registry and identity
- Registries use the name TB-500 for a different molecule: the FDA record TB-500 (UNII QHK6Z47GTG, CAS 885340-08-9) is the acetylated seven-residue fragment Ac-LKKTETQ, residues 17 to 23 of the 43-residue chain (18 to 24 in UniProt's numbering), C38H68N10O14, average mass 889.0, which a 2012 analytical paper identified in a product sold under that name. FDA GSRS, PubChem, PubMed
- The full 43-residue acetylated chain this page describes carries the INN timbetasin (WHO Proposed INN List 118, also USAN), UNII 2D5MRE3SSY, CAS 77591-33-4, and its acetate is filed as UNII 945CRJ0XZ0, CAS 1346423-89-9. FDA GSRS 2D5MRE3SSY, FDA GSRS 945CRJ0XZ0
- The full chain weighs about 4963.5 and the fragment about 889.0. PubChem 16132341, PubChem 62707662
- In UniProt (P62328, gene TMSB4X) the chain is residues 2 to 44 of human thymosin beta-4: the initiator methionine is cleaved off and the serine that follows it carries the N-acetyl group. UniProt
- For thymosin beta-4 the monoisotopic ions are at m/z 827.755 (6+) and 993.105 (5+), from a monoisotopic mass of 4960.486. PubChem, NIST
A listing in these registers identifies a substance; it is not an approval of this line.
TB-500 beside GHK-Cu and BPC-157
TB-500 works out at $1.034 per mg at 10mg (TB10), its lowest by the single box. Its neighbours, on price alone: GHK-Cu at $0.052 per mg at 100mg (CU100), 401.9 g/mol, set side by side in GHK-Cu vs TB-500; BPC-157 at $0.553 per mg at 10mg (BC10), 1,419.6 g/mol, set side by side in BPC-157 vs TB-500.
Also set side by side: Thymosin Alpha-1 vs TB-500.
Reading a TB-500 (thymosin beta-4 acetate) certificate of analysis (COA)
Identity by mass. Average mass 4963.5 (C212H350N56O78S). In electrospray the protonated ions come near m/z 4964.5 (singly charged), m/z 2482.8 (doubly charged), m/z 1655.5 (3x charged), m/z 1241.9 (4x charged); on our certificates the measured mass is matched to the calculated average mass, within about one unit.
- Oxidation: 1 methionine, which oxidises to the sulfoxide. The sulfoxide makes the chain 16 heavier.
- Deamidation: 1 asparagine and 3 glutamines. The deamidated form is 0.984 heavier and a little more negatively charged, inside the tolerance of the average-mass line; telling it apart takes a high-resolution mass, which the certificate does not carry.
- N-terminus: capped with an acetyl group, so there is no free N-terminal amine.
- Charge: near neutral pH about -3, acidic, with 9 basic residues, so it takes multiple charges in electrospray.
Worked out from what the sheet holds for this line; the batch certificate is the record. How to read one, and verify a batch number.
Buy TB-500 (thymosin beta-4 acetate) in bulk
TB-500 (thymosin beta-4 acetate) is sold in bulk by the sealed box of ten vials, and every account starts at list price. Two discounts can lower it, the size of one order (from $5,000 of goods) or the account’s tier (from lifetime paid spend), and the better one applies, never both. Priced below on TB10, 10mg x 10 vials, the best-priced strength.
| Discount | Earned by | Off goods | TB10 per box | Per mg |
|---|---|---|---|---|
| List | Every account, any order | none | $103.40 | $1.034 |
| Order size | $5,000 of goods in one order | 5% | $98.23 | $0.982 |
| Order size | $10,000 of goods in one order | 10% | $93.06 | $0.931 |
| Order size | $20,000 of goods in one order | 15% | $87.89 | $0.879 |
| Order size | $50,000 of goods in one order | 20% | $82.72 | $0.827 |
| Silver tier | $5,000 lifetime paid spend | 3% | $100.30 | $1.003 |
| Gold tier | $15,000 lifetime paid spend | 6% | $97.20 | $0.972 |
| Platinum tier | $50,000 lifetime paid spend | 10% | $93.06 | $0.931 |
| Diamond tier | $100,000 lifetime paid spend | 15% | $87.89 | $0.879 |
Thresholds in USD on goods, before freight; the discount is worked out at checkout and shown on the proforma.
Specification
The limits this compound is supplied to.
| Purity | ≥ 98.0 % (RP-HPLC, 220 nm, area normalisation) |
|---|---|
| Identity | ESI-MS against a calculated average mass of 4963.5 |
| Any single related substance | ≤ 1.0 % |
| Water | ≤ 8.0 % (Karl Fischer) |
| Acetate | ≤ 15.0 % (ion chromatography), as the acetate salt |
| Residual solvents | Acetonitrile ≤ 410 ppm; TFA ≤ 1.0 % |
| Net content | Label claim ± 5 % |
| Closure | 2 mL glass vial, bromobutyl stopper, aluminium flip-off seal |
| Storage | −20 °C, dark and dry; brief ambient transit tolerated |
| Shelf life | 24 months from manufacture; retest date on the batch record |
Order TB-500 (thymosin beta-4 acetate)
One box of TB5, 5mg x 10 vials, $71.40 a box. Every strength.
Questions about TB-500 (thymosin beta-4 acetate)
Is timbetasin the same as TB-500?
For this line, yes; in the registries, no. Timbetasin is the international non-proprietary name of the full 43-residue acetylated thymosin beta-4 chain, 4,963.5, which is what the line sold as TB-500 (thymosin beta-4 acetate) is. FDA’s register gives the name TB-500 to a different molecule, the seven-residue fragment Ac-LKKTETQ at 889.0, 4,074.5 lighter than the 43-residue chain this line supplies. The certificate and the vial label carry TB-500 (thymosin beta-4 acetate), which is the name the batch is released under.
What are TB-500’s sequence, formula, molecular weight and CAS number?
Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES, the full 43-residue thymosin beta-4 with an acetylated N-terminus: C212H350N56O78S, molecular weight (average mass) 4,963.5, CAS 77591-33-4. Registries use the name TB-500 for a different molecule, the seven-residue fragment Ac-LKKTETQ (CAS 885340-08-9).
How much does TB-500 (thymosin beta-4 acetate) cost?
From $71.40 a sealed box of 10 vials, up to $103.40 for the largest strength sold singly, which works out at $1.034 per mg at its best-priced size. TB2 is special order, 50 boxes at least, at $28.00 a box. To a US address, freight is included from $1,000 of goods; below that it is the carrier’s rate for the carton or a flat $35.00, and to another country the desk quotes it; either way the figure is on the proforma before you pay. Every strength and its price per vial is in this page’s price table.
Which TB-500 (thymosin beta-4 acetate) size is cheapest per mg?
TB10, 10mg x 10 vials, at $1.034 per mg, which is 28 percent less per mg than TB5, at $1.428 per mg. Larger vials cost less per mg across this range, so match the vial to the size of the work first, then compare per mg.
Can I buy a single vial of TB-500 (thymosin beta-4 acetate)?
No. One sealed box of ten vials is the smallest quantity of a regular line; for TB-500 (thymosin beta-4 acetate) that is TB5, 5mg x 10 vials, at $71.40. A first order must reach $100 of goods, so TB5 alone takes two boxes ($142.80) or one box beside other lines. TB2 is special order and takes a minimum of 50 boxes. A box is sealed at fill with its batch number on it, and splitting one would break the link between the vials and their certificate.
Which TB-500 (thymosin beta-4 acetate) strengths are in stock today?
TB5 at $71.40 a box, TB10 at $103.40 a box (running low). TB2 is special order: brought in on a 50-box minimum rather than held in stock; ask the desk for the date before ordering.
How is TB-500 (thymosin beta-4 acetate) stored?
At minus 20 degrees Celsius, dark and dry. Lyophilised powder tolerates a short spell at ambient temperature in transit, which is why boxes ship without ice. Storage and handling.
What is in a box of TB-500 (thymosin beta-4 acetate)?
Ten sealed vials of one strength, each labelled with the product code, the strength and the batch number; the trade also calls a box a 10-vial kit. TB-500 (thymosin beta-4 acetate) is supplied as a powder in a sealed glass vial and in no other presentation. Boxes are not split.
Is a certificate of analysis (COA) provided for TB-500 (thymosin beta-4 acetate)?
Yes. For TB-500 (thymosin beta-4 acetate) the batch certificate reports its purity, net content and identity by mass spectrometry. The other lines on this page are the specification it is made to, and the desk answers for them on a particular batch. The certificate is sent with the shipment, and again on request, and any batch number can be verified on the certificate page.
Is this for human use?
No. Everything here is supplied for laboratory research only, to trade accounts, and is not for human or animal consumption. The research-use page sets out who can buy and what is not sold.