Semaglutide vs Liraglutide
Strength for strength, Semaglutide costs less per mg at the three strengths both sell by the single box: at 5mg $0.524 per mg against $0.727 (SM5, LIR5), at 10mg $0.384 per mg against $0.603 (SM10, LIR10), at 30mg $0.301 per mg against $0.523 (SM30, LIR30). Semaglutide is offered in 7 strengths (5mg to 50mg), Liraglutide in 3 (5mg to 30mg); Semaglutide has 2 on the shelf today, Liraglutide none (made to order, about four weeks).
Prices revised · USD per box of ten · freight included to US addresses from $1,000 of goods · COA per batch · research use only · New to us? What can be checked before you pay
What differs between Semaglutide and Liraglutide
The same 31-residue GLP-1 backbone, lipidated at lysine 26 in both. Liraglutide keeps the native alanine at position 8 and carries a C16 palmitic acid on a single gamma-glutamate; semaglutide has Aib at 8 and a C18 diacid on a longer linker. Their masses sit about 360 units apart. On the list they are priced as separate lines and listed separately; the per-milligram figures below are the practical comparison.
| Detail | Semaglutide | Liraglutide |
|---|---|---|
| Best per mg, by the box | $0.301 per mg (SM30) | $0.523 per mg (LIR30) |
| Best per mg, special order included | $0.283 per mg (SM50, 50 boxes) | $0.523 per mg (LIR30) |
| Price per box sold singly | $26.20 to $90.38 | $36.36 to $156.86 |
| In 50-box lots, per box | $50.90 to $141.28 | None |
| Strengths offered | 7: 5mg, 10mg, 15mg, 20mg, 30mg, 40mg, 50mg | 3: 5mg, 10mg, 30mg |
| Highest price per mg | $0.524 per mg (SM5) | $0.727 per mg (LIR5) |
| On the shelf today | 2 of 7 strengths | 0 of 3 strengths |
| Range | GLP-1 & Metabolic | GLP-1 & Metabolic |
| Also called | GLP-1 SG, GLP-1 Sema, NN9535 and NNC 0113-0217 | NN2211 and NNC 90-1170 |
| Form | Lyophilised powder | Lyophilised powder |
| Molecular weight | 4,113.6 g/mol | 3,751.3 g/mol |
| Formula | C187 |
C172 |
| CAS number | 910463-68-2 | 204656-20-2 |
| Release limit | Purity ≥ 98.0 % by RP-HPLC | Purity ≥ 98.0 % by RP-HPLC |
Each line’s own page: Semaglutide and Liraglutide. Reading either certificate: how to read a peptide COA. Checking a batch: verify a batch number. Every line priced: the price list. Checking another supplier’s quote: the price per mg calculator.
Strength for strength
Every strength both are offered in, per mg, the lower figure in bold; stock as this page was opened. Counting special-order lines, sold in 50-box lots, the lowest for Semaglutide is $0.283 per mg (50mg, SM50); for Liraglutide it is still LIR30, made to order by the single box, at $0.523 per mg.
| Strength | Semaglutide | Liraglutide |
|---|---|---|
| 5mg | $0.524 per mg (lower) (SM5, made to order) | $0.727 per mg (LIR5, made to order) |
| 10mg | $0.384 per mg (lower) (SM10, made to order) | $0.603 per mg (LIR10, made to order) |
| 30mg | $0.301 per mg (lower) (SM30, in stock) | $0.523 per mg (LIR30, made to order) |
Every strength of both
Compared elsewhere
Tirzepatide vs Semaglutide
At 30mg: $0.330 per mg against $0.301; 12 strengths against 7.
Cagrilintide vs Semaglutide
At 10mg: $1.618 per mg (Cagrilintide, 50-box lots) against $0.384; 2 strengths against 7.
Retatrutide vs Semaglutide
At 30mg: $0.553 per mg against $0.301; 10 strengths against 7.
Liraglutide vs Tirzepatide
At 30mg: $0.523 per mg against $0.330; 3 strengths against 12.
Questions
What is the difference between Semaglutide and Liraglutide?
The same 31-residue GLP-1 backbone, lipidated at lysine 26 in both. Liraglutide keeps the native alanine at position 8 and carries a C16 palmitic acid on a single gamma-glutamate; semaglutide has Aib at 8 and a C18 diacid on a longer linker.
How far is each from native GLP-1?
Liraglutide changes one residue of human GLP-1 (7-37), arginine for lysine 34, and carries palmitic acid on a gamma-glutamate at lysine 26. Semaglutide keeps that arginine, puts Aib in place of the alanine at 8, and carries an 18-carbon diacid on a gamma-glutamate and two AEEA units at the same lysine. Both end in the native free glycine acid; the list’s unmodified line, native GLP-1, keeps lysines at 26 and 34.
Which is cheaper per mg, Semaglutide or Liraglutide?
Strength for strength, Semaglutide costs less per mg at the three strengths both sell by the single box: at 5mg $0.524 per mg against $0.727 (SM5, LIR5), at 10mg $0.384 per mg against $0.603 (SM10, LIR10), at 30mg $0.301 per mg against $0.523 (SM30, LIR30).
What are the molecular weights of Semaglutide and Liraglutide?
Semaglutide’s calculated average mass is 4,113.6 g/mol and Liraglutide’s 3,751.3 g/mol, 362.3 apart; in electrospray the ions come at m/z 1372.2 and 1029.4 (3+ and 4+) for Semaglutide against 1251.4 and 938.8 (3+ and 4+) for Liraglutide. On each certificate the measured mass is matched to the line’s calculated average mass, within about one unit, as how to read a peptide COA sets out.
Are Semaglutide and Liraglutide made to the same specification?
Yes: both are supplied to purity not less than 98.0 percent by RP-HPLC and net content within 5 percent of label, and each certificate reports those with a measured mass, matched to the calculated figure on each sheet. The retest date is on the batch record. What differs is each molecule’s own chemistry, described on its compound page.
Structural facts from each compound’s sheet and profile; prices and stock from the list at the moment this page was opened. How to compare strengths on price.