Semaglutide wholesale
Semaglutide, development code NN9535. Bulk peptide powder in 10-vial kits, for sale in the USA and abroad: price and cost per mg
About Semaglutide
Acylated GLP-1 analogue, 31 residues. 7 vial strengths, 5mg to 50mg, from $26.20 to $90.38 per box of ten, in US dollars. 2 strengths are on the shelf, leaving in 1 to 2 business days; the rest are made to order in about four weeks or special order (50-box minimum), as marked.
Documents Specification sheet Verify a batch How to read the certificate What the purity figure means The mass result, explained
Semaglutide price per box, per vial and per mg
| Code | Strength | Per box | Per vial | Per mg | Stock | Order |
|---|---|---|---|---|---|---|
| SM5 | 5mg x 10 vials | $26.20 | $2.62 | $0.524 per mg | Made to order, 4 weeks | |
| SM10 | 10mg x 10 vials | $38.44 | $3.84 | $0.384 per mg | Made to order, 4 weeks | |
| SM15 | 15mg x 10 vials | $50.90 | $5.09 | $0.339 per mg | Special order, 50-box minimum | |
| SM20 | 20mg x 10 vials | $64.41 | $6.44 | $0.322 per mg | Low stock | |
| SM30 | 30mg x 10 vials | $90.38 | $9.04 | $0.301 per mg | In stock | |
| SM40 | 40mg x 10 vials | $115.31 | $11.53 | $0.288 per mg | Special order, 50-box minimum | |
| SM50 | 50mg x 10 vials | $141.28 | $14.13 | Lowest, 50 boxes $0.283 per mg | Special order, 50-box minimum |
On the shelf, leaving in 1 to 2 business days: SM20, SM30. The others are made to order (about four weeks) or special order, as marked.
Ships from the USA: to US addresses at our risk until delivered (DAP), freight included from $1,000 of goods; to Canada and most other countries through the desk · on-shelf lines leave in 1 to 2 business days, then 1 to 3 business days in US transit · COA per batch · proforma in USD, paid by card, Wise, e-Transfer (Canada), Bitcoin or USDT · prices revised
Stock key
- In stock
- on the shelf, leaves in 1 to 2 business days once payment clears
- Low stock
- on the shelf and running low; leaves in 1 to 2 business days
- Ships in 1 week
- on its way in
- Ships in 2 weeks
- on order
- Made to order, 4 weeks
- made for the order, about four weeks
- Special order, 50-box minimum
- brought in on a 50-box minimum rather than held in stock; the desk confirms the date before you pay
Prices are in US dollars per sealed box. Per unit is the box price over the milligrams, millilitres or units in the box.
Semaglutide in brief
Semaglutide comes in 7 strengths from 5mg to 50mg per vial, each a sealed box of ten, from $26.20 to $90.38 a box for the strengths sold singly. Per mg the spread is wide: SM30 (30mg x 10 vials) works out at $0.301 per mg against $0.524 per mg for SM5 (5mg x 10 vials), 43 percent less for the same mg, because the vial, the fill and the testing cost about the same whatever the vial holds.
2 of the 7 strengths are on the shelf today (SM20 and SM30) and leave in 1 to 2 business days after payment clears; SM20 is running low. SM5 and SM10 are made to order, about four weeks. SM15, SM40 and SM50 are special order: brought in on a 50-box minimum rather than held in stock; ask the desk for the date before ordering.
What Semaglutide is
Semaglutide is a 31-residue analogue of human GLP-1 (7-37). Three changes distinguish it from the native hormone: Aib at position 8 in place of alanine, arginine at position 34 in place of lysine, and a C18 fatty diacid attached to the lysine at position 26 through a gamma-glutamate and two mini-PEG units. The single lysine left in the chain is the one that carries the lipid, which is why the substitution at 34 is there. It is also supplied co-formulated with cagrilintide, in equal amounts, as Cagrilintide 2.5mg + Semaglutide 2.5mg, Cagrilintide 5mg + Semaglutide 5mg and Cagrilintide 10mg + Semaglutide 10mg. Liraglutide, the earlier acylated GLP-1 analogue here, has alanine at 8 where semaglutide has Aib, and a C16 palmitic acid on lysine 26 in place of the C18 diacid; the two are priced side by side in Semaglutide vs Liraglutide.
The backbone has one tryptophan, one glutamine and no methionine or cysteine. The related substances to expect are small: the deamidated form, a tryptophan oxidation product if the powder has seen light, and traces of the des-lipid or doubly acylated chains from synthesis.
Registry and identity
- The codes NN9535 and NNC 0113-0217 both denote semaglutide, which FDA's GSRS files as UNII 53AXN4NNHX (CAS 910463-68-2), DrugBank as DB13928, ChEBI as 167574 and ChEMBL as CHEMBL2108724. FDA GSRS
- GSRS also files the D-lysine form of semaglutide's acylated residue (UNII DZ64EH7X4P, CAS 2847079-23-4); a chain made with that epimer weighs exactly what semaglutide weighs; telling the two apart takes HPLC run beside a reference of the epimer, which the certificate does not carry. FDA GSRS
- Against liraglutide on this list, semaglutide swaps alanine 8 for Aib and the palmitoyl gamma-glutamate on lysine 26 for a C18 diacid with gamma-glutamate and two AEEA units, which adds 362.3 to the average mass, 4,113.6 against 3,751.3. PubChem 56843331, PubChem 16134956
- Two side-chain reagent impurities carry semaglutide's name in GSRS, impurity 66 (the C18 diacid as an ethyl ester) and impurity 71 (an extra beta-alanine in the linker); built into the chain they would weigh 28.03 and 71.04 more than the parent. FDA GSRS N9THF9F95N, FDA GSRS GQC8BAB6JB
- At high resolution semaglutide's monoisotopic ions are at m/z 1371.379 (3+) and 1028.786 (4+), from a monoisotopic mass of 4111.115. PubChem, NIST
A listing in these registers identifies a substance; it is not an approval of this line.
Semaglutide beside Tirzepatide and Retatrutide
Semaglutide works out at $0.301 per mg at 30mg (SM30), its lowest by the single box. Its neighbours, on price alone: Tirzepatide at $0.305 per mg at 60mg (TR60), 4,813.5 g/mol, set side by side in Tirzepatide vs Semaglutide; Retatrutide at $0.453 per mg at 60mg (RT60), 4,731.4 g/mol, set side by side in Retatrutide vs Semaglutide.
Also set side by side: Retatrutide vs Tirzepatide vs Semaglutide, Semaglutide vs Liraglutide and Cagrilintide vs Semaglutide.
Reading a Semaglutide certificate of analysis (COA)
Identity by mass. Average mass 4113.6 (C187H291N45O59). In electrospray the protonated ions come near m/z 4114.6 (singly charged), m/z 2057.8 (doubly charged), m/z 1372.2 (3x charged), m/z 1029.4 (4x charged); on our certificates the measured mass is matched to the calculated average mass, within about one unit.
- Oxidation: 1 tryptophan, which oxidises to kynurenine and hydroxy forms under light. Kynurenine makes the chain 4 heavier and a hydroxy tryptophan 16.
- Deamidation: 1 glutamine. The deamidated form is 0.984 heavier and a little more negatively charged, inside the tolerance of the average-mass line; telling it apart takes a high-resolution mass, which the certificate does not carry.
- Charge: near neutral pH about -4, acidic, counting the two free carboxyls of its lipid side chain.
Worked out from what the sheet holds for this line; the batch certificate is the record. How to read one, and verify a batch number.
Buy Semaglutide in bulk
Semaglutide is sold in bulk by the sealed box of ten vials, and every account starts at list price. Two discounts can lower it, the size of one order (from $5,000 of goods) or the account’s tier (from lifetime paid spend), and the better one applies, never both. Priced below on SM30, 30mg x 10 vials, the best-priced strength.
| Discount | Earned by | Off goods | SM30 per box | Per mg |
|---|---|---|---|---|
| List | Every account, any order | none | $90.38 | $0.301 |
| Order size | $5,000 of goods in one order | 5% | $85.86 | $0.286 |
| Order size | $10,000 of goods in one order | 10% | $81.34 | $0.271 |
| Order size | $20,000 of goods in one order | 15% | $76.82 | $0.256 |
| Order size | $50,000 of goods in one order | 20% | $72.30 | $0.241 |
| Silver tier | $5,000 lifetime paid spend | 3% | $87.67 | $0.292 |
| Gold tier | $15,000 lifetime paid spend | 6% | $84.96 | $0.283 |
| Platinum tier | $50,000 lifetime paid spend | 10% | $81.34 | $0.271 |
| Diamond tier | $100,000 lifetime paid spend | 15% | $76.82 | $0.256 |
Thresholds in USD on goods, before freight; the discount is worked out at checkout and shown on the proforma.
Specification
The limits this compound is supplied to.
| Purity | ≥ 98.0 % (RP-HPLC, 220 nm, area normalisation) |
|---|---|
| Identity | ESI-MS against a calculated average mass of 4113.6 |
| Any single related substance | ≤ 1.0 % |
| Water | ≤ 8.0 % (Karl Fischer) |
| Acetate | ≤ 15.0 % (ion chromatography), as the acetate salt |
| Residual solvents | Acetonitrile ≤ 410 ppm; TFA ≤ 1.0 % |
| Net content | Label claim ± 5 % |
| Closure | 2 mL glass vial, bromobutyl stopper, aluminium flip-off seal |
| Storage | −20 °C, dark and dry; brief ambient transit tolerated |
| Shelf life | 24 months from manufacture; retest date on the batch record |
Order Semaglutide
One box of SM20, 20mg x 10 vials, $64.41 a box. Every strength.
Questions about Semaglutide
Is GLP-1 SG, or GLP-1 Sema, the same as Semaglutide?
Yes. GLP-1 SG, GLP-1 Sema and Semaglutide are names for the same thing. GLP-1 SG and GLP-1 Sema are trade nicknames some sellers use for semaglutide; native GLP-1, which this list sells as its own line, GLP-1 (native), is a different peptide, and the line is released as semaglutide, development code NN9535. The certificate and the vial label carry Semaglutide, which is the name the batch is released under.
What are Semaglutide’s formula, molecular weight and CAS number?
C187H291N45O59, molecular weight (average mass) 4,113.6 and monoisotopic 4,111.115, CAS 910463-68-2 (FDA GSRS UNII 53AXN4NNHX). The figure is the whole conjugate: the C18 fatty diacid joined through a gamma-glutamate and two AEEA spacers to the lysine at position 26 is included.
How much does Semaglutide cost?
From $26.20 a sealed box of 10 vials, up to $90.38 for the largest strength sold singly, which works out at $0.301 per mg at its best-priced size. SM5, the cheapest box sold singly, is made to order, about four weeks; the cheapest on the shelf is SM20 at $64.41. Special-order strengths, with a 50-box minimum, run from $50.90 to $141.28 a box. To a US address, freight is included from $1,000 of goods; below that it is the carrier’s rate for the carton or a flat $35.00, and to another country the desk quotes it; either way the figure is on the proforma before you pay. Every strength and its price per vial is in this page’s price table.
Which Semaglutide size is cheapest per mg?
Of the sizes sold by the single box, SM30, 30mg x 10 vials, at $0.301 per mg, which is 43 percent less per mg than SM5, at $0.524 per mg. Larger vials cost less per mg across the sizes sold by the single box, so match the vial to the size of the work first, then compare per mg. Sold only by special order, SM50 is lower still, at $0.283 per mg, with a 50-box minimum.
Can I buy a single vial of Semaglutide?
No. One sealed box of ten vials is the smallest quantity of a regular line; for Semaglutide that is SM5, 5mg x 10 vials, at $26.20. A first order must reach $100 of goods, so SM5 alone takes four boxes ($104.80) or one box beside other lines. SM15, SM40 and SM50 are special order and take a minimum of 50 boxes each. A box is sealed at fill with its batch number on it, and splitting one would break the link between the vials and their certificate.
Which Semaglutide strengths are in stock today?
SM20 at $64.41 a box (running low), SM30 at $90.38 a box. SM5 and SM10 are made to order, about four weeks. SM15, SM40 and SM50 are special order: brought in on a 50-box minimum rather than held in stock; ask the desk for the date before ordering.
How is Semaglutide stored?
At minus 20 degrees Celsius, dark and dry. Lyophilised powder tolerates a short spell at ambient temperature in transit, which is why boxes ship without ice. Storage and handling.
What is in a box of Semaglutide?
Ten sealed vials of one strength, each labelled with the product code, the strength and the batch number; the trade also calls a box a 10-vial kit. Semaglutide is supplied as a powder in a sealed glass vial and in no other presentation. Boxes are not split.
Is a certificate of analysis (COA) provided for Semaglutide?
Yes. For Semaglutide the batch certificate reports its purity, net content and identity by mass spectrometry. The other lines on this page are the specification it is made to, and the desk answers for them on a particular batch. The certificate is sent with the shipment, and again on request, and any batch number can be verified on the certificate page.
Is this for human use?
No. Everything here is supplied for laboratory research only, to trade accounts, and is not for human or animal consumption. The research-use page sets out who can buy and what is not sold.