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Tirzepatide vs Semaglutide

Strength for strength, Semaglutide costs less per mg at the three strengths both sell by the single box: at 10mg $0.384 per mg against $0.442 (SM10, TR10), at 20mg $0.322 per mg against $0.354 (SM20, TR20), at 30mg $0.301 per mg against $0.330 (SM30, TR30). Tirzepatide is offered in 12 strengths (5mg to 120mg), Semaglutide in 7 (5mg to 50mg); 3 and 2 of those are on the shelf today.

Prices revised 27 October 2026 · USD per box of ten · freight included to US addresses from $1,000 of goods · COA per batch · research use only · New to us? What can be checked before you pay

What differs between Tirzepatide and Semaglutide

Tirzepatide is a 39-residue chain built on GIP and semaglutide a 31-residue GLP-1 analogue, and each carries a fatty diacid on one lysine through the same kind of linker, a gamma-glutamate and two AEEA spacers: C20 on tirzepatide’s lysine 20, C18 on semaglutide’s lysine 26. Tirzepatide’s chain has Aib in place of residues 2 and 13 and a C-terminal amide; semaglutide’s is human GLP-1 (7-37) changed at 8 to Aib and at 34 to arginine. Both have a single tryptophan and no methionine; tirzepatide has the extra glutamine, two deamidation sites to semaglutide’s one. With the lipids attached the two differ by 699.9 in average mass: 4,813.5 for tirzepatide and 4,113.6 for semaglutide. Both are released to the same purity and net-content limits; which one a laboratory orders is set by its work, and this page compares only price, strengths, stock and the certificate.

Detail	Tirzepatide	Semaglutide
Best per mg, by the box	$0.305 per mg (TR60)	$0.301 per mg (SM30)
Best per mg, special order included	$0.276 per mg (TR120, 50 boxes)	$0.283 per mg (SM50, 50 boxes)
Price per box sold singly	$44.20 to $182.84	$26.20 to $90.38
In 50-box lots, per box	$33.40 to $331.38	$50.90 to $141.28
Strengths offered	12: 5mg, 10mg, 15mg, 20mg, 30mg, 40mg, 45mg, 50mg, 60mg, 80mg, 100mg, 120mg	7: 5mg, 10mg, 15mg, 20mg, 30mg, 40mg, 50mg
Highest price per mg	$0.668 per mg (TR5, 50 boxes)	$0.524 per mg (SM5)
On the shelf today	3 of 12 strengths	2 of 7 strengths
Range	GLP-1 & Metabolic	GLP-1 & Metabolic
Also called	GLP-2 TZ, GLP-2 Tirz and LY3298176	GLP-1 SG, GLP-1 Sema, NN9535 and NNC 0113-0217
Form	Lyophilised powder	Lyophilised powder
Molecular weight	4,813.5 g/mol	4,113.6 g/mol
Formula	C₂₂₅H₃₄₈N₄₈O₆₈	C₁₈₇H₂₉₁N₄₅O₅₉
CAS number	2023788-19-2	910463-68-2
Release limit	Purity ≥ 98.0 % by RP-HPLC	Purity ≥ 98.0 % by RP-HPLC

Each line’s own page: Tirzepatide and Semaglutide. Reading either certificate: how to read a peptide COA. Checking a batch: verify a batch number. Every line priced: the price list. Checking another supplier’s quote: the price per mg calculator.

Strength for strength

Every strength both are offered in, per mg, the lower figure in bold; stock as this page was opened. Counting special-order lines, sold in 50-box lots, the lowest figures are $0.276 per mg for Tirzepatide (120mg, TR120) and $0.283 per mg for Semaglutide (50mg, SM50).

Strength	Tirzepatide	Semaglutide
5mg	$0.668 per mg (TR5, special order, 50 boxes)	$0.524 per mg (lower) (SM5, made to order)
10mg	$0.442 per mg (TR10, made to order)	$0.384 per mg (lower) (SM10, made to order)
15mg	$0.377 per mg (TR15, low stock)	$0.339 per mg (lower) (SM15, special order, 50 boxes)
20mg	$0.354 per mg (TR20, made to order)	$0.322 per mg (lower) (SM20, low stock)
30mg	$0.330 per mg (TR30, in stock)	$0.301 per mg (lower) (SM30, in stock)
40mg	$0.317 per mg (TR40, low stock)	$0.288 per mg (lower) (SM40, special order, 50 boxes)
50mg	$0.291 per mg (TR50, special order, 50 boxes)	$0.283 per mg (lower) (SM50, special order, 50 boxes)

Every strength of both

Code	Compound	Strength	Per box	Per vial	Per unit	Stock
TR5	Tirzepatide	5mg x 10 vials	$33.40	$3.34	$0.668 per mg	Special order, 50-box minimum
TR10	Tirzepatide	10mg x 10 vials	$44.20	$4.42	$0.442 per mg	Made to order, 4 weeks
TR15	Tirzepatide	15mg x 10 vials	$56.54	$5.65	$0.377 per mg	Low stock
TR20	Tirzepatide	20mg x 10 vials	$70.84	$7.08	$0.354 per mg	Made to order, 4 weeks
TR30	Tirzepatide	30mg x 10 vials	$98.85	$9.89	$0.330 per mg	In stock
TR40	Tirzepatide	40mg x 10 vials	$126.82	$12.68	$0.317 per mg	Low stock
TR45	Tirzepatide	45mg x 10 vials	$131.93	$13.19	$0.293 per mg	Special order, 50-box minimum
TR50	Tirzepatide	50mg x 10 vials	$145.43	$14.54	$0.291 per mg	Special order, 50-box minimum
TR60	Tirzepatide	60mg x 10 vials	$182.84	$18.28	$0.305 per mg	Made to order, 4 weeks
TR80	Tirzepatide	80mg x 10 vials	$225.42	$22.54	$0.282 per mg	Special order, 50-box minimum
TR100	Tirzepatide	100mg x 10 vials	$278.40	$27.84	$0.278 per mg	Special order, 50-box minimum
TR120	Tirzepatide	120mg x 10 vials	$331.38	$33.14	$0.276 per mg	Special order, 50-box minimum
SM5	Semaglutide	5mg x 10 vials	$26.20	$2.62	$0.524 per mg	Made to order, 4 weeks
SM10	Semaglutide	10mg x 10 vials	$38.44	$3.84	$0.384 per mg	Made to order, 4 weeks
SM15	Semaglutide	15mg x 10 vials	$50.90	$5.09	$0.339 per mg	Special order, 50-box minimum
SM20	Semaglutide	20mg x 10 vials	$64.41	$6.44	$0.322 per mg	Low stock
SM30	Semaglutide	30mg x 10 vials	$90.38	$9.04	$0.301 per mg	In stock
SM40	Semaglutide	40mg x 10 vials	$115.31	$11.53	$0.288 per mg	Special order, 50-box minimum
SM50	Semaglutide	50mg x 10 vials	$141.28	$14.13	$0.283 per mg	Special order, 50-box minimum

Compared elsewhere

Retatrutide vs Tirzepatide vs Semaglutide

All three side by side: price per mg by the single box, strengths and the shelf.

Retatrutide vs Tirzepatide

At 60mg: $0.453 per mg against $0.305; 10 strengths against 12.

Liraglutide vs Tirzepatide

At 30mg: $0.523 per mg against $0.330; 3 strengths against 12.

Semaglutide vs Liraglutide

At 30mg: $0.301 per mg against $0.523; 7 strengths against 3.

Cagrilintide vs Semaglutide

At 10mg: $1.618 per mg (Cagrilintide, 50-box lots) against $0.384; 2 strengths against 7.

Retatrutide vs Semaglutide

At 30mg: $0.553 per mg against $0.301; 10 strengths against 7.

Questions

What is the difference between Tirzepatide and Semaglutide?

Which registry numbers belong to tirzepatide and semaglutide?

Tirzepatide is CAS 2023788-19-2 (FDA UNII OYN3CCI6QE), 4,813.5 by average mass; semaglutide is CAS 910463-68-2 (UNII 53AXN4NNHX), 4,113.6. FDA’s register also lists substances named after each that are not the peptide itself: for tirzepatide, its acylated lysine (UNII NVV1P9GCY2) and the protected building block used to make it (UNII 628F25FNZ3); for semaglutide, the D-lysine form of its acylated residue: a chain made with that epimer weighs exactly what semaglutide weighs, so telling the two apart takes HPLC run beside a reference of the epimer, and two side-chain impurities, an ethyl ester of the C18 diacid and a linker with an extra beta-alanine, which would weigh 28.03 and 71.04 more.

Which is cheaper per mg, Tirzepatide or Semaglutide?

What are the molecular weights of Tirzepatide and Semaglutide?

Tirzepatide’s calculated average mass is 4,813.5 g/mol and Semaglutide’s 4,113.6 g/mol, 699.9 apart; in electrospray the ions come at m/z 1605.5 and 1204.4 (3+ and 4+) for Tirzepatide against 1372.2 and 1029.4 (3+ and 4+) for Semaglutide. On each certificate the measured mass is matched to the line’s calculated average mass, within about one unit, as how to read a peptide COA sets out.

Are Tirzepatide and Semaglutide made to the same specification?

Yes: both are supplied to purity not less than 98.0 percent by RP-HPLC and net content within 5 percent of label, and each certificate reports those with a measured mass, matched to the calculated figure on each sheet. The retest date is on the batch record. What differs is each molecule’s own chemistry, described on its compound page.

Structural facts from each compound’s sheet and profile; prices and stock from the list at the moment this page was opened. How to compare strengths on price.