Retatrutide vs Tirzepatide
Strength for strength, Tirzepatide costs less per mg at the six strengths both sell by the single box: at 10mg $0.442 per mg against $0.808 (TR10, RT10), at 20mg $0.354 per mg against $0.683 (TR20, RT20), at 60mg $0.305 per mg against $0.453 (TR60, RT60), and this page’s table has the other three. Retatrutide is offered in 10 strengths (5mg to 100mg), Tirzepatide in 12 (5mg to 120mg); 2 and 3 of those are on the shelf today.
Prices revised · USD per box of ten · freight included to US addresses from $1,000 of goods · COA per batch · research use only · New to us? What can be checked before you pay
What differs between Retatrutide and Tirzepatide
Both are 39-residue acylated peptides on a GIP-type backbone with a C20 fatty diacid, and both are sold here as lyophilised powder in boxes of ten. The differences a buyer sees are in the vial: tirzepatide is offered here in more strengths and reaches a larger vial, and both sheets carry a formula and a mass: retatrutide C221H342N46O68 at 4,731.4, tirzepatide C225H348N48O68 at 4,813.5, about 82 apart. Structurally, retatrutide has Aib at positions 2 and 20 with the lipid on lysine 17; tirzepatide has Aib at 2 and 13 with the lipid on lysine 20.
| Detail | Retatrutide | Tirzepatide |
|---|---|---|
| Best per mg, by the box | $0.453 per mg (RT60) | $0.305 per mg (TR60) |
| Best per mg, special order included | $0.419 per mg (RT100, 50 boxes) | $0.276 per mg (TR120, 50 boxes) |
| Price per box sold singly | $80.80 to $271.78 | $44.20 to $182.84 |
| In 50-box lots, per box | $62.80 to $418.64 | $33.40 to $331.38 |
| Strengths offered | 10: 5mg, 10mg, 15mg, 20mg, 30mg, 40mg, 50mg, 60mg, 80mg, 100mg | 12: 5mg, 10mg, 15mg, 20mg, 30mg, 40mg, 45mg, 50mg, 60mg, 80mg, 100mg, 120mg |
| Highest price per mg | $1.256 per mg (RT5, 50 boxes) | $0.668 per mg (TR5, 50 boxes) |
| On the shelf today | 2 of 10 strengths | 3 of 12 strengths |
| Range | GLP-1 & Metabolic | GLP-1 & Metabolic |
| Also called | GLP-3 RT, GLP-3 Reta and LY3437943 | GLP-2 TZ, GLP-2 Tirz and LY3298176 |
| Form | Lyophilised powder | Lyophilised powder |
| Molecular weight | 4,731.4 g/mol | 4,813.5 g/mol |
| Formula | C221 |
C225 |
| CAS number | 2381089-83-2 | 2023788-19-2 |
| Release limit | Purity ≥ 98.0 % by RP-HPLC | Purity ≥ 98.0 % by RP-HPLC |
Each line’s own page: Retatrutide and Tirzepatide. Reading either certificate: how to read a peptide COA. Checking a batch: verify a batch number. Every line priced: the price list. Checking another supplier’s quote: the price per mg calculator.
Strength for strength
Every strength both are offered in, per mg, the lower figure in bold; stock as this page was opened. Counting special-order lines, sold in 50-box lots, the lowest figures are $0.276 per mg for Tirzepatide (120mg, TR120) and $0.419 per mg for Retatrutide (100mg, RT100).
| Strength | Retatrutide | Tirzepatide |
|---|---|---|
| 5mg | $1.256 per mg (RT5, special order, 50 boxes) | $0.668 per mg (lower) (TR5, special order, 50 boxes) |
| 10mg | $0.808 per mg (RT10, in stock) | $0.442 per mg (lower) (TR10, made to order) |
| 15mg | $0.748 per mg (RT15, made to order) | $0.377 per mg (lower) (TR15, low stock) |
| 20mg | $0.683 per mg (RT20, in stock) | $0.354 per mg (lower) (TR20, made to order) |
| 30mg | $0.553 per mg (RT30, made to order) | $0.330 per mg (lower) (TR30, in stock) |
| 40mg | $0.534 per mg (RT40, made to order) | $0.317 per mg (lower) (TR40, low stock) |
| 50mg | $0.458 per mg (RT50, special order, 50 boxes) | $0.291 per mg (lower) (TR50, special order, 50 boxes) |
| 60mg | $0.453 per mg (RT60, made to order) | $0.305 per mg (lower) (TR60, made to order) |
| 80mg | $0.422 per mg (RT80, special order, 50 boxes) | $0.282 per mg (lower) (TR80, special order, 50 boxes) |
| 100mg | $0.419 per mg (RT100, special order, 50 boxes) | $0.278 per mg (lower) (TR100, special order, 50 boxes) |
Every strength of both
Compared elsewhere
Retatrutide vs Tirzepatide vs Semaglutide
All three side by side: price per mg by the single box, strengths and the shelf.
Retatrutide vs Survodutide
At 10mg: $0.808 per mg against $1.901 (Survodutide, 50-box lots); 10 strengths against 1.
Mazdutide vs Retatrutide
At 10mg: $1.091 per mg (Mazdutide, 50-box lots) against $0.808; 2 strengths against 10.
Retatrutide vs Semaglutide
At 30mg: $0.553 per mg against $0.301; 10 strengths against 7.
Tirzepatide vs Semaglutide
At 30mg: $0.330 per mg against $0.301; 12 strengths against 7.
Liraglutide vs Tirzepatide
At 30mg: $0.523 per mg against $0.330; 3 strengths against 12.
Questions
What is the difference between Retatrutide and Tirzepatide?
Both are 39-residue acylated peptides on a GIP-type backbone with a C20 fatty diacid, and both are sold here as lyophilised powder in boxes of ten. The differences a buyer sees are in the vial: tirzepatide is offered here in more strengths and reaches a larger vial, and both sheets carry a formula and a mass: retatrutide C221H342N46O68 at 4,731.4, tirzepatide C225H348N48O68 at 4,813.5, about 82 apart.
Where in the two formulas do the 82.1 units between retatrutide and tirzepatide lie?
In carbon, hydrogen and nitrogen alone: C4H6N2 is the difference between C225H348N48O68 and C221H342N46O68; both formulas hold the same 68 oxygens. The chains are the same length, 39 residues, and each carries a C20 diacid, so the gap comes from the residues that fill the chain, not from its length or its lipid. At four charges the gap is 20.5 in m/z, 1,204.4 against 1,183.9.
Which is cheaper per mg, Retatrutide or Tirzepatide?
Strength for strength, Tirzepatide costs less per mg at the six strengths both sell by the single box: at 10mg $0.442 per mg against $0.808 (TR10, RT10), at 20mg $0.354 per mg against $0.683 (TR20, RT20), at 60mg $0.305 per mg against $0.453 (TR60, RT60), and this page’s table has the other three.
What are the molecular weights of Retatrutide and Tirzepatide?
Retatrutide’s calculated average mass is 4,731.42 g/mol and Tirzepatide’s 4,813.53 g/mol, 82.11 apart; in electrospray the ions come at m/z 1578.1 and 1183.9 (3+ and 4+) for Retatrutide against 1605.5 and 1204.4 (3+ and 4+) for Tirzepatide. On each certificate the measured mass is matched to the line’s calculated average mass, within about one unit, as how to read a peptide COA sets out.
Are Retatrutide and Tirzepatide made to the same specification?
Yes: both are supplied to purity not less than 98.0 percent by RP-HPLC and net content within 5 percent of label, and each certificate reports those with a measured mass, matched to the calculated figure on each sheet. The retest date is on the batch record. What differs is each molecule’s own chemistry, described on its compound page.
Structural facts from each compound’s sheet and profile; prices and stock from the list at the moment this page was opened. How to compare strengths on price.